If you a tourist and in need to puke for two days, take the 101. It's fun to take 101 for about two hours but then its done with it. If you are on a biz trip take the 5 and be done with it in about 5 hours. I usually try to do down and back up same day trips.
Btw, driving down and back to SF takes pretty much the same time then flying Southwest (go to airport, park, check-in, wait for boarding, fly 45 minutes, get rental, drive to the studio lot -> and back). One big difference, no TSA and you are in control of the departure time. Get some lunch at harris ranch, they have a tesla supercharger station there too.
Have not done it in a karma. Still looking for the right one. Hopefully next week.